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CARDIOPULMONARY SUPPORT AND PHYSIOLOGY - The effects of heparin and extracorporeal circulation on platelet counts and platelet microaggregation during cardiopulmonary bypass - Heparinization caused platelet activation, which increased existent platelet microaggregation ex vivo. During extracorporeal circulation, the loss of total circulating platelets was not associated with a significant change in the unaggregated platelet; count; existent platelet microaggregates were lost. Heparin may promote platelet loss by increasing microaggregate numbers/ / Muriithi, Elijah W / C.V. Mosby / Journal of thoracic and cardiovascular s / 538-543p. / 2000

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