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ACADEMIA AND CLINIC - Methodologic Pitfalls in the Determination of Genetic Anticipation: The Case of Crohn Disease - The term genetic anticipation is used when genetically transmitted disease manifests at increasingly younger ages with each succeeding generation: That is, if the offspring of patients develop the disease, they will tend to do so at an earlier age than their parents. According to this study among patients with Crohn disease, apparent genetic anticipation can be explained by observational biases without invoking any additional genetic influences./ / Picco, M F / American College of Physicians] / Annals of internal medicine / 1124-1129p. / 2001

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