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SCIENTIFIC PAPERS - High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells - DPC4 (deleted in pancreatic carcinoma, locus 4 or MADH4/SMAD4) is a tumor-suppressor gene mutated in approximately half of human pancreatic adenocarcinomas. The current study reports the use of a stably integrated DPC4-reporter system in human pancreatic cells to screen a library of 16,320 random compounds, searching for chemicals that interact with the DPC4 tumor-suppressive pathway. The screening identified several compounds capable of augmenting and inhibiting DPC4-specific luciferase reporter activity. The identification of such compounds will enable us to further understand this critical signal transduction pathway and may identify potential candidates for rational therapeutic intervention./ / Sohn, Taylor A / J. B. Lippincott [etc.] / Annals of surgery / 696-703p. / 2001

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