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LABORATORY INVESTIGATIONS - Facilitated Uptake of Fentanyl, but Not Alfentanil, by Human Pulmonary Endothelial Cells - Saturable, facilitated fentanyl uptake was observed in human lung microvascular endothelial cells and was inhibited by verapamil but was unaffected by a blocking antibody to P-glycoprotein. Alfentanil uptake by these cells occurred by diffusion alone. These results suggest that specific uptake and sequestration of fentanyl by human lung microvascular endothelial cells may be the mechanisms of its extensive pulmonary uptake/
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