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LABORATORY INVESTIGATIONS - Disposition of Bupivacaine and Its Metabolites in the Maternal, Placental, and Fetal Compartments in Rats - Maternally administered bupivacaine becomes undetectable in both maternal and fetal blood within 4 h, whereas its major metabolite in the rat, 3'-hydroxybupivacaine, remains in the maternal and fetal tissues. Bupivacaine and 3'-hydroxybupivacaine significantly accumulate in the placenta and amnion./
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