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RESEARCH AND MEASUREMENT ISSUES - Health-Related Quality of Life and Health Care Costs in Severe, Refractory Irritable Bowel Syndrome - In this cross-sectional survey, both abdominal and psychological symptoms were independently associated with impaired health-related quality of life in patients with severe irritable bowel syndrome. Optimal treatment is likely to require a holistic approach. Since health care and loss of productivity costs are not clearly associated with irritable bowel syndrome symptoms, alleviation of them will not necessarily lead to reduced costs./
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