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REVIEW - Muscle Cachexia: Current Concepts of lntracellular Mechanisms and Molecular Regulation - Muscle cachexia, commonly seen in patients with severe injury, sepsis, and cancer, is mainly caused by increased myofibrillar protein breakdown. Muscle protein breakdown in catabolic muscle reflects calcium/calpain-regulated release of myofilaments from the sarcomere and subsequent ubiquitination of the myofilaments and degradation by the 26S proteasome./
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