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Molecular Mechanisms Contributing to Necrotizing Enterocolitis - The authors investigated a role of the inducible form of cyclooxygenase (COX-2) in the pathogenesis of necrotizing enterocolitis (NEC). COX-2 protein expression was markedly increased in the intestinal epithelium of infants with NEC. Inhibitors of COX-2 may prove to be useful therapeutic agents to ameliorate intestinal injury in NEC./
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