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Technical Issues and Pathologic Implications of Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer Patients - Sentinel node biopsy can be better accomplished when a combined approach is used because the detection rate increases significantly from 73.8% (113/153) with Patent Blue-V alone, to 94.1% (144/153) with RGS alone, up to 98.7% (151/153) with Patent Blue-V and RGS. Micrometastasis in the sN implies a low risk of metastatic involvement of non-sN, mostly in pT1a-pT1b tumours, while macrometastases in the sN are associated with a substantial risk of metastases in non-sN, even in small tumours./
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