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Basic Science - Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion - An established New Zealand white rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine on fusion. Whereas autograft induced fusion in 25% of the nicotine-exposed rabbits, osteogenic protein-1 induced fusion in 100% of the animals./
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