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CARDIOTHORACIC TRANSPLANTATION - Adenovirus-mediated genetic manipulation of the myocardial b-adrenergic signaling system in transplanted hearts - Ex vivo manipulation of b-adrenergic receptor signaling offers a novel form of gene therapy to enhance myocardial function. Experimental cardiac allografts perfused with transgenes encoding either the human b2-adrenergic receptor or a peptide inhibitor of b-adrenergic receptor desensitization had significantly improved baseline and agonist-mediated LV performance compared with that found in controls/
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