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Basic Science - Anti-Apoptotic Effects of IGF-1 and PDGF on Human Intervertebral Disc Cells In Vitro - Apoptosis (programmed cell death) is believed to be one of the mechanisms by which cell number decreases in the aging/degenerating disc. In this study, 50 and 500 ng/mL insulin-like growth factor-1 and 100 ng/mL platelet-derived growth factor significantly reduced or prevented apoptosis in cultured human disc cells from the anulus/
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