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REGIONAL ANESTHESIA AND PAIN MEDICINE - GENERAL ARTICLES - Interaction Between Volatile Anesthetics and Hypoxia in Porcine Tracheal Smooth Muscle - IMPLICATIONS: Hypoxia inhibits agonist-induced tracheal smooth muscle contraction with an increase in free Ca2+ (Ca2+)i, which comes from intracellular Ca2+ stores. Hypoxia also potentiates the inhibitory effect of volatile anesthetics on airway smooth muscle contraction. Conversely, there is a possibility that the treatment of asthmatic patients with oxygen partially attenuates the inhibitory effect of volatile anesthetics on airway smooth muscle contractility/
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