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CLINICAL INVESTIGATIONS - Pulmonary Disposition of Propofol in Surgical Patients - A significant amount of propofol was taken up during the first pass through the human lung, and most of the uptaken propofol was released back into the circulation by back diffusion when the blood concentrations decreased. No pulmonary extraction of propofol was observed at the pseudo-steady state, suggesting that the lungs do not seem to be a site contributing to the extrahepatic metabolism of propofol in the human./
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