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Original Articles - Prenatal Exposure to Nitrofen Induces Fryns Phenotype in Mice - Timed-pregnant mice gavage-fed 25 mg of the herbicide nitrogen on day 8 of gestation developed the severe craniofacial defects of Fryns syndrome in 26% of cases. Generalized delay in chondrogenesis and osteogenesis was noted throughout the skeleton, along with reduction in the number of lumbar vertebrae./
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