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REGIONAL ANESTHESIA - More Epidural than Intravenous Sufentanil is Required to Provide Comparable Postoperative Pain Relief - IMPLICATIONS: More epidural than IV sufentanil was required to provide comparable postoperative pain relief and similar plasma sufentanil concentrations. These data suggest that when sufentanil is administered in small-dose boluses, much of the drug is absorbed into the epidural fat and that the primary mechanism by which epidurally administered sufentanil produces analgesia is via systemic absorption./
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