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LABORATORY INVESTIGATIONS - Possible Involvement of Cyclic Adenosine Monophosphate-independent Mechanism in the Positive Chronotropic Effect of Norepinephrine in the Isolated Guinea Pig Right Atrium - Amrinone and 3-isobutyl-1-methylxanthine potentiated the positive chronotropic effect of forskolin but not that of norepinephrine. The hyperpolarization-activated inward current inhibitor cesium chloride and the calcium channel inhibitor verapamil inhibited the positive chronotropic effect of norepinephrine without affecting that of forskolin./
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