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CARDIOVASCULAR ANESTHESIA (Society of Cardiovascular Anesthesiologists) - The Effects of Propofol on the Contractility of Failing and Nonfailing Human Heart Muscles - IMPLICATIONS: Propofol was shown to exert direct negative inotropic effects in nonfailing and failing human myocardium, but only at supratherapeutic concentrations. The net effect on contractility at clinical concentrations is related to an increase in myofilament sensitivity to Ca2- balancing decreased uptake by the sarcoplasmic reticulum./
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