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CARDIOVASCULAR ANESTHESIA - (Society of Cardiovascular Anesthesiologists) - Loss of Physiologic Hepatic Blood Flow Control ("Hepatic Arterial Buffer Response") During CO2-Pneumoperitoneum in the Rat - IMPLICATIONS: We investigated the effect of CO 2)-pneumoperitoneum on liver blood flow, hepatic tissue oxygenation (PO2) and liver enzyme release. CO2-insufflation reduces portal venous flow without a compensatory increase of hepatic arterial flow ("hepatic arterial buffer response"), resulting in reduced hepatic PO2 and increased ratios of serum alanine aminotransferase to serum aspartate aminotransferase./
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