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PAIN MEDICINE - A Prostaglandin E2 Receptor Subtype EP1, Receptor Antagonist (ONO-8711) Reduces Hyperalgesia, Allodynia, and C-fos Gene Expression in Rats with Chronic Nerve Constriction - IMPLICATIONS: We examined whether a prostaglandin E2 receptor subtype EP1, receptor antagonist abrogates neuropathic pain induced by chronic constriction injury model in rats. The EP1 receptor antagonist significantly reduced hyperalgasia, allodynia, and c-fos positive cells. These findings suggested that EP1 receptor antagonists may have a role in treatment of neuropathic pain./
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