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CARDIOPULMONARY SUPPORT AND PHYSIOLOGY - Aprotinin administration in the pericardial cavity does not prevent platelet activation - In a double-blind placebo-controlled study of 13 patients, we demonstrated that administration of aprotinin into the pericardial cavity during CPB, at concentrations similar to the dosage used for its systemic application, does not inhibit the reduction of platelet surface GPIb expression or the formation of microparticles or platelet complexes/
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