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Core-Shell Functional Nanospheres for Oligonucleotide Delivery. III. Stealth Nanospheres Polymethyl methacrylate-based stealth and functional nanospheres, specifically designed for the reversible adsorption of oligonucleotides (ODN), were prepared by emulsion polymerization of methyl methacrylate in the presence of an ionic comonomer, namely a quaternary ammonium salt of 2-(dimethylamino)ethyl methacrylate, and a nonionic comonomer, namely a poly(ethylene glycol) methacrylate. The nanosphere size is substantially affected by the amount of both the nonionic and ionic comonomers. By appropriately adjusting the concentrations of the ionic and nonionic comonomers, the quaternary ammonium group and PEG chain surface densities can be finely tuned. Accordingly, a great variety of core-shell-type nanospheres, with the following structure, able to bind ODN and to induce dysopsonic effect, can be obtained/
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| No. | 권호·제본정보 보기 | 소장처 | 소장사항 | 청구기호 | 구독 | 최근입수호 |
|---|---|---|---|---|---|---|
| 1 | 중앙도서관/3층 연속간행물(보존)/ | 547 J86A | 구독중 | Vol.45 No.16 | ||
| 2 | 중앙도서관/3층 연속간행물실/ | 547 J86A | 구독중 | Vol.45 No.24 |
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