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Basic Science - Matrix Metalloproteinases and Aggrecanase: Their Role in Disorders of the Human Intervertebral Disc - Several types of matrix metalloproteinases have been found in diseased intervertebral discs, being most common in herniated discs. Enzymes can be produced by both the invading vascular cells and the native disc cells. Evidence for aggrecanase activity was demonstrated in degenerate discs./
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