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Research papers - Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: Interplay of metal binding, pH and molecular packing - The crystal structures of ZnCa con A at pH 6.15 and CdCd con A at pH 5.0 reveal the role of the crystal environment in the structure of the protein surface. Alternative molecular packings of the con A subunits are established to satisfy the interdependent conditions of pH, quaternary structure and crystal packing. These packings are further stabilized by the formation of supplementary metal-binding sites, S3 and S4./
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