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Basic Science - Nitric Oxide Mediates the Change of Proteoglycan Synthesis in the Human Lumbar Intervertebral Disc in Response To Hydrostatic Pressure - Effects of hydrostatic pressure on proteoglycan (PG) synthesis and nitric oxide (NO) production in lumbar discs were studied. Nitric Oxide appears to be a constituent of the mechano-transduction pathways that influence PG synthesis. Mechanisms of NO are involved in regulation of disc cell metabolism under stress and in the process of disc degeneration./
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