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ANESTHETIC PHARMACOLOGY - (International Society for Anaesthetic Pharmacology) - Modulation of NMDA Receptor Function by Ketamine and Magnesium: Part I - IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner. These findings may explain, in part, why combinations of ketamine and Mg2+ are more effective analgesics than either compound alone./
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