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ANESTHETIC PHARMACOLOGY - (International Society for Anaesthetic Pharmacology) - Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner - IMPLICATIONS: Voltage-gated sodium channels mediate the initiation and propagation of action potentials along the sarcolemma. Results from our study show that those channels are targeted and blocked in a concentration- and voltage-dependent manner by propofol. This mechanism may contribute to the reduction in muscle excitability./
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