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ANESTHETIC PHARMACOLOGY - (International Society for Anaesthetic Pharmacology) - The Effects of Benzodiazepines on Human Opioid Receptor Binding and Function - IMPLICATIONS: Several human and animal studies have shown analgesic effects of benzodiazepines after spinal injection. Our results show that large concentrations of midazolam, chlordiazepoxide, and diazepam displace the binding of (3H)-diprenorphine -- An opiate radioligand from k receptors. In an in vitro functional assay, midazolam is a weak agonist at the d-opioid receptor, whereas all three benzodiazepines are k-Opioid agonists. These findings may partially explain the mechanism of benzodiazepine-induced spinal analgesia./
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| No. | 권호·제본정보 보기 | 소장처 | 소장사항 | 청구기호 | 구독 | 최근입수호 |
|---|---|---|---|---|---|---|
| 1 | 의학도서관/연속간행물/ | 617.96 A579 | 구독중단 | Vol.113 no.6 |
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