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ANESTHETIC PHARMACOLOGY - (International Society for Anaesthetic Pharmacology) - Clonidine Suppresses Plasma and Cerebrospinal Fluid Concentrations of TNF-a During the Perioperative Period - IMPLICATIONS: Preoperative administration of clonidine decreases both plasma and cerebrospinal fluid concentrations of inflammatory cytokines, resulting in perioperative analgesia and decreased sympathetic tone./
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