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ANESTHETIC PHARMACOLOGY (International Society for Anaesthetic Pharmacology) - The Inhibitory Effect of Bupivacaine on Prostaglandin E2 (EP1) Receptor Functioning: Mechanism of Action - IMPLICATIONS: Clinically relevant bupivacaine concentrations inhibit prostaglandin E2 EP1 subtype signaling. This may explain the effects of regional anesthesia on physiologic responses such as fever, inflammation, and hyperalgesia during the perioperative period./
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