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Original Articles - Acute Alterations in Muscle Flap Microcirculation During Tumor Necrosis Factor Alpha-Induced Inflammation - In a rat cremaster-muscle model of ischemia-reperfusion, arterial preinfusion of TNF-a resulted in 3- to 4-fold increases in rolling, adhering, and transmigrating leukocytes during the first 3 hours of reperfusion. In addition a vasodilatory effect was noted in third- and fourth-order arterioles./
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