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CRITICAL CARE AND TRAUMA - The Pharmacokinetics of Cisatracurium in Patients with Acute Respiratory Distress Syndrome - IMPLICATIONS: We studied the pharmacokinetics of cisatracurium in six patients treated for respiratory distress syndrome by continuous muscle relaxation. A deep degree of neuromuscular blockade corresponding to abolition of two responses at the orbicularis oculi to train-of-four stimulation was obtained in all patients. The pharmacokinetic variables observed in these severely ill patients were similar to those of anesthetized patients. No accumulation of laudanosine was seen. Cisatracurium appears to be suitable when continuous muscle relaxation is required in critically ill patients./ / Dhonneur, Gilles / International Anesthesia Research Society] / Anesthesia and analgesia / 400-404p. / 2001

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