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LABORATORY INVESTIGATIONS - Activation of m- and d-Opioid Receptors Causes Presynaptic Inhibition of Glutamatergic Excitation in Neocortical Neurons - Intracellular recordings from neocortical neurons in vitro provide evidence for a m- and d-opioid receptor-induced presynaptic inhibition of glutamate receptor-mediated excitatory synaptic transmission. Postsynaptic actions became evident only at high concentrations of d-receptor agonists./
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Ostermeier, Andreas M
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American Society of Anesthesiologists, etc.]
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2000
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| 2 |
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LABORATORY INVESTIGATIONS - Addition of Sodium Bicarbonate to Lidocaine Decreases the Duration of Peripheral Nerve Block in the Rat - When 1% commercial lidocaine is alkalinized with 8.4% sodium bicarbonate (10:1) to a pH of 7.8, the duration of sciatic nerve block in the rat is less than half of that produced with either unalkalined fidocaine (pH = 6.6) or lidocaine alkalinized to the same pH with sodium hydroxide. This decrease in duration is not observed when lidocaine is coinjected with epinephrine, but onset is accelerated with bicarbonate./
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Sinnott, Catherine J
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American Society of Anesthesiologists, etc.]
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2000
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| 3 |
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LABORATORY INVESTIGATIONS - Alterations in Ascending Dorsal Horn Neurons by a Surgical Incision in the Rat Foot/
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American Society of Anesthesiologists, etc.]
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2000
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| 4 |
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LABORATORY INVESTIGATIONS - Altered Expression of Cardiac Myosin Isozymes Associated with the Malignant Hyperthermia Genotype in Swine/
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American Society of Anesthesiologists, etc.]
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2000
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| 5 |
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LABORATORY INVESTIGATIONS - Block of Human Heart hH1 Sodium Channels by the Enantiomers of Bupivacaine - Differences in bupivacaine stereoselectivity and intrinsic affinity between hH1 and m1 Na+ channels are small and most likely of minor clinical relevance. Amino acid residues in positions hH1-F1760, hH1-N1765, and hH1-N406 contribute to binding of bupivacaine enantiomers in hH1 Na+ channels./
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Nau, Carla
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American Society of Anesthesiologists, etc.]
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2000
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| 6 |
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LABORATORY INVESTIGATIONS - Cardiac Troponin I and Myocardial Contusion in the Rabbit - In a model of global controlled and graded cardiac trauma, a severe myocardial contusion induced a sustained ventricular dysfunction associated with a prolonged and biphasic release of cardiac troponin I. The peak concentration of cardiac troponin I was correlated with myocardial injury and cardiac functional consequences of the blow/
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Okubo, Naomitsu
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American Society of Anesthesiologists, etc.]
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2000
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| 7 |
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LABORATORY INVESTIGATIONS - Cerebral Histopathology following Portal Venous Infusion of Bacteria in a Chronic Porcine Model - Intraabdominal bacteria infusion induces brain damage/
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Bogdanski, Ralph
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American Society of Anesthesiologists, etc.]
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2000
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| 8 |
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LABORATORY INVESTIGATIONS - Comparative Ventricular Electrophysiologic Effect of Racemic Bupivacaine, Levobupivacaine, and Ropivacaine on the Isolated Rabbit Heart - In the isolated rabbit heart, racemic bupivacaine, levobupivacaine, and ropivacaine increase QRS duration in the ratio 1:0.4:0.25. This impairment of conduction was rate dependent in approximately the same ratio/
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Mazoit, Jean Xavier
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American Society of Anesthesiologists, etc.]
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2000
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| 9 |
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LABORATORY INVESTIGATIONS - Compatibility of Different Colloid Plasma Expanders with Perflubron Emulsion/
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American Society of Anesthesiologists, etc.]
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2000
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| 10 |
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LABORATORY INVESTIGATIONS - Desflurane Induces Only Minor Ca2+ Release from the Sarcoplasmic Reticulum of Mammalian Skeletal Muscle - Findings that desflurane induces only small calcium release in comparison with that of equimolar sevoflurane in vitro support the clinical observation that desflurane appears to be a weak malignant hyperthermia trigger/
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Kunst, Gudrun
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American Society of Anesthesiologists, etc.]
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2000
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| 11 |
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LABORATORY INVESTIGATIONS - Differential Effects of Halothane and Thiopental on Surfactant Protein C Messenger RNA In Vivo and In Vitro in Rats - Halothane and thiopental modulate surfactant-associated protein C messenger RNA expression in vivo and in vitro in rats/
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Paugam-Burtz, Catherine
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American Society of Anesthesiologists, etc.]
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2000
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| 12 |
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LABORATORY INVESTIGATIONS - Disposition of Bupivacaine and Its Metabolites in the Maternal, Placental, and Fetal Compartments in Rats - Maternally administered bupivacaine becomes undetectable in both maternal and fetal blood within 4 h, whereas its major metabolite in the rat, 3'-hydroxybupivacaine, remains in the maternal and fetal tissues. Bupivacaine and 3'-hydroxybupivacaine significantly accumulate in the placenta and amnion./
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Morishima, Hisayo O
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American Society of Anesthesiologists, etc.]
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2000
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| 13 |
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LABORATORY INVESTIGATIONS - Dual Effects of Intravenous Anesthetics on the Function of Norepinephrine Transporters/
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American Society of Anesthesiologists, etc.]
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2000
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| 14 |
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LABORATORY INVESTIGATIONS - Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels: Comparison with Isoflurane and Ethanol - NMDA receptors and neuronal nicotinic acetylcholine receptors composed of the b2 subunit are sensitive to nitrous oxide and xenon./
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Yamakura, Tomohiro
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American Society of Anesthesiologists, etc.]
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2000
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| 15 |
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LABORATORY INVESTIGATIONS - Effects of Isoflurane, Sevoflurane, and Halothane on Myofilament Ca2+ Sensitivity and Sarcoplasmic Reticulum Ca2+ Release in Rat Ventricular Myocytes - Depressed myofilament Ca2+ sensitivity and decreased sarcoplasmic reticulum (SR) Ca2+ content contribute to the negative inotropy of isoflurane and halothane. Sevoflurane does not appear to depress myofilament Ca2+ sensitivity or SR Ca2+ content but decreases the fraction of SR Ca2+ released; this accounts for the negative inotropic effect of sevoflurane./
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Davies, Lucinda A
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American Society of Anesthesiologists, etc.]
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2000
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| 16 |
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LABORATORY INVESTIGATIONS - Effects of Thiopental and Its Optical Isomers on Nicotinic Acetylcholine Receptors - Thiopental at clinical concentrations can substantially inhibit neuronal and muscle nicotinic acetylcholine receptors, but the effects of its optical isomers do not mirror those for general anesthesia/
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Downie, David L
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American Society of Anesthesiologists, etc.]
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2000
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| 17 |
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LABORATORY INVESTIGATIONS - Enflurane Directly Depresses Glutamate AMPA and NMDA Currents in Mouse Spinal Cord Motor Neurons Independent of Actions on GABAA or Glycine Receptors - The results of the current study show a direct depressant effect of enflurane on glutamate responses in spinal cord motor neurons. Depression persists if inhibitory receptors are blocked. These results are consistent with the hypothesis that immobility as an anesthetic endpoint results from actions on motor neurons, and that direct depression of glutamate excitatory responses plays a role independent of enhancement of g-aminobutyric acid AA or glycine inhibition./
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Cheng, Gong
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American Society of Anesthesiologists, etc.]
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2000
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| 18 |
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LABORATORY INVESTIGATIONS - Facilitated Uptake of Fentanyl, but Not Alfentanil, by Human Pulmonary Endothelial Cells - Saturable, facilitated fentanyl uptake was observed in human lung microvascular endothelial cells and was inhibited by verapamil but was unaffected by a blocking antibody to P-glycoprotein. Alfentanil uptake by these cells occurred by diffusion alone. These results suggest that specific uptake and sequestration of fentanyl by human lung microvascular endothelial cells may be the mechanisms of its extensive pulmonary uptake/
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Waters, Christopher M
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American Society of Anesthesiologists, etc.]
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2000
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| 19 |
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LABORATORY INVESTIGATIONS - In Vitro Compound A Formation in a Computer-controlled Closed-circuit Anesthetic Apparatus: Comparison with a Classical Valve Circuit - Compound A formation and sodalime temperatures during in vitro computer-controlled closed-circuit sevoflurane administration are lower than previously reported and lower than in a classical valve-containing closed circuit./
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Versichelen, Linda F M
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American Society of Anesthesiologists, etc.]
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2000
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| 20 |
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LABORATORY INVESTIGATIONS - Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model/
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American Society of Anesthesiologists, etc.]
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2000
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기사
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