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SCIENTIFIC PAPERS - High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells - DPC4 (deleted in pancreatic carcinoma, locus 4 or MADH4/SMAD4) is a tumor-suppressor gene mutated in approximately half of human pancreatic adenocarcinomas. The current study reports the use of a stably integrated DPC4-reporter system in human pancreatic cells to screen a library of 16,320 random compounds, searching for chemicals that interact with the DPC4 tumor-suppressive pathway. The screening identified several compounds capable of augmenting and inhibiting DPC4-specific luciferase reporter activity. The identification of such compounds will enable us to further understand this critical signal transduction pathway and may identify potential candidates for rational therapeutic intervention./
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| No. | 권호·제본정보 보기 | 소장처 | 소장사항 | 청구기호 | 구독 | 최근입수호 |
|---|---|---|---|---|---|---|
| 1 | 의학도서관/연속간행물/ | 617 A613 | 구독중단 | Vol.254 no.6 |
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